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mBio
Vol. 14, No. 61 December 2023

Respiration supports intraphagosomal filamentation and escape of Candida albicans from macrophages

Nicola T. Case, Johannes Westman, Michael T. Hallett, Jonathan Plumb, Aiman Farheen, Michelle E. Maxson, Jessie MacAlpine, Leah E. Cowen

For the human fungal pathogen Candida albicans, metabolic flexibility and the ability to transition between yeast and filamentous growth states are key virulence traits that enable disease in the host. These traits are particularly important during the interaction of C. albicans with macrophages, where the fungus must utilize multiple alternative carbon sources to survive after being phagocytosed, and filamentation is coupled to fungal escape and immune cell death...

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mBio
Vol. 5, No. 225 March 2025

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